Author

L. Valcarcel-Jimenez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

C. Frezza· 2 shared C. Rogerson· 2 shared C. Schmidt· 2 shared M. Yang· 2 shared A. Mora· 1 shared A. N. Mora· 1 shared A. Speed· 1 shared C. Yong· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

C. Frezza

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

FOXA2 controls the anti-oxidant response in FH-deficient cells

C. Rogerson, M. Sciacovelli, L. A. Maddalena, L. Valcarcel-Jimenez, C. Schmidt, M. Yang, E. Ivanova, J. Kent, A. Mora, D. Cheeseman, J. S. Carroll, G. Kelsey, C. Frezza

This study identifies FOXA2 as a key transcription factor regulating the anti-oxidant response in FH-deficient cells, independent of NRF2, and highlights its role in metabolic rewiring.

bioRxiv · Jul 4, 2022Cancer Biology

HIRA loss transforms FH-deficient cells

L. Valcarcel-Jimenez, C. Rogerson, C. Yong, C. Schmidt, M. Yang, V. Harle, V. Offord, K. Wong, A. N. Mora, A. Speed, V. Caraffini, M. G. B. Tran, E. R. Maher, G. D. Stewart, S. Vanharanta, , C. Frezza

This study identifies HIRA depletion as a factor that enhances proliferation and invasion of Fh1-deficient cells, revealing a mechanism involving MYC activation and nucleotide metabolism.

bioRxiv · Jun 4, 2022Cancer Biology