Author

C. Yong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 2 Organism:mouse· 2 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

A. D. Rao· 1 shared A. Kaushik· 1 shared A. N. Mora· 1 shared A. Speed· 1 shared A. Tarangelo· 1 shared B. Faubert· 1 shared B. S. P. Slusher· 1 shared C. Frezza· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

A. D. Rao

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3 papers

Recent·Most cited

In-vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma

A. Kaushik, L. K. Burroughs, A. Tarangelo, M. Ragavan, C.-Y. Wu, X. Li, K. Ahumada, V. T. Tcheuyap, F. Saatchi, Q. Do, C. Yong, T. Rosales, C. Stevens, A. D. Rao, B. Faubert, , R. J. DeBerardinis

The paper identifies multiple glutamine metabolism pathways in ccRCC tumorgrafts and shows that targeting amidotransferase activity reduces tumor growth.

bioRxiv · Oct 31, 2022Cancer Biology

HIRA loss transforms FH-deficient cells

L. Valcarcel-Jimenez, C. Rogerson, C. Yong, C. Schmidt, M. Yang, V. Harle, V. Offord, K. Wong, A. N. Mora, A. Speed, V. Caraffini, M. G. B. Tran, E. R. Maher, G. D. Stewart, S. Vanharanta, , C. Frezza

This study identifies HIRA depletion as a factor that enhances proliferation and invasion of Fh1-deficient cells, revealing a mechanism involving MYC activation and nucleotide metabolism.

bioRxiv · Jun 4, 2022Cancer Biology

Locally-invasive, castrate-resistant prostate cancer in a Pten/Trp53 double knockout mouse model of prostate cancer monitored with non-invasive bioluminescent imaging

C. Yong, D. Moose, N. Bannick, M. Vanneste, R. Svensson, P. Breheny, J. Brown, M. Cohen, M. Henry

The paper improves a prostate cancer mouse model with a bioluminescent reporter to monitor tumor progression and shows that double knockout of Pten and Trp53 leads to castrate-resistant, locally invasive tumors.

bioRxiv · Apr 23, 2020Cancer Biology