Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2
R. K. Singh, A. Soliman, G. Guaitoli, E. Störmer, F. von Zweydorf, T. Dal Maso, L. Van Rillaer, S. H. Schmidt, D. Chatterjee, E. Pardon, S. Knapp, E. J. Kennedy, J. Steyaert, F. W. Herberg, A. Kortholt, , W. Versees
This study identifies and characterizes Nanobodies that modulate LRRK2 activity through non-ATP-competitive mechanisms, offering new tools for Parkinson's disease research and therapy.
bioRxiv · Aug 30, 2021Biochemistry