Author

E. J. Kennedy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Kortholt· 1 shared A. M. Bowcock· 1 shared A. Polo· 1 shared A. Soliman· 1 shared B. Brahmia· 1 shared C. J. Gloeckner· 1 shared D. Chatterjee· 1 shared D. Hinds· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperBiochemistry

A. Kortholt

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Targeting phosphoRab-RILPL Interactions as a Strategy to Downregulate Pathogenic LRRK2 in Parkinson's Disease

K. Alexander, Y. Naaldijk, R. Fasiczka, B. Brahmia, T. Chen, S. Hilfiker, E. J. Kennedy

This paper demonstrates that constrained peptides mimicking phosphorylated Rab8 can block RILPL interactions and restore ciliogenesis and centrosomal cohesion defects in cells with mutant LRRK2.

bioRxiv · Nov 6, 2023Biochemistry

Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2

R. K. Singh, A. Soliman, G. Guaitoli, E. Störmer, F. von Zweydorf, T. Dal Maso, L. Van Rillaer, S. H. Schmidt, D. Chatterjee, E. Pardon, S. Knapp, E. J. Kennedy, J. Steyaert, F. W. Herberg, A. Kortholt, , W. Versees

This study identifies and characterizes Nanobodies that modulate LRRK2 activity through non-ATP-competitive mechanisms, offering new tools for Parkinson's disease research and therapy.

bioRxiv · Aug 30, 2021Biochemistry

Kinetics characterization of ASXL1/2-mediated allosteric regulation of BAP1 deubiquitinase

H. Peng, J. Cassel, D. McCracken, J. W. Prokop, P. R. Collop, A. Polo, S. Joshi, J. P. Mandell, K. Ayyanathan, D. Hinds, S. B. Malkowicz, J. W. Harbour, A. M. Bowcock, J. Salvino, E. J. Kennedy, , F. J. Rauscher

This study characterizes the kinetics and stoichiometry of BAP1 and ASXL2 interactions, revealing their structural and functional properties in deubiquitinase activity.

bioRxiv · Feb 24, 2020Cancer Biology