Apelin-VEGF-C mRNA delivery as therapeutic for the treatment of secondary lymphedema
A. Lamaa, J. Creff, E. Benuzzi, F. Pujol, T. Draia-Nicolau, M. Nougue, L. Verdu, F. Morfoisse, E. Lacazette, P. Valet, B. Chaput, F. Gross, R. Gayon, P. Bouille, J. Malloizel-Delaunay, , B. Garmy-Susini
This study identifies apelin as a therapeutic molecule for secondary lymphedema, showing it enhances lymphatic function through VEGF-C and pathways involving Akt and eNOS, with a novel RNA delivery system for clinical evaluation.
bioRxiv · Jan 5, 2023 · PreprintPathology