Author

L. W. Graeff

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Biology Disciplines

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Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

B. T. K. Nguyen· 1 shared E. Smith· 1 shared J. W. Modell· 1 shared M. J. Stoltzfus· 1 shared R. E. Workman· 1 shared S. M. Sebald· 1 shared T. Pammi· 1 shared

Activity by Year

2020-2020 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperMicrobiology

B. T. K. Nguyen

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1 paper

Recent·Most cited

A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression

R. E. Workman, T. Pammi, B. T. K. Nguyen, L. W. Graeff, E. Smith, S. M. Sebald, M. J. Stoltzfus, J. W. Modell

The paper shows that a long-form tracrRNA acts as a natural single guide to repress Cas9 expression, revealing a regulatory mechanism in CRISPR-Cas systems.

bioRxiv · May 21, 2020Microbiology