Author

R. E. Workman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:bacteria (other)· 2 Research Focus:differential expression· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Assay:DNA methylation· 1

Frequent Co-Authors

J. W. Modell· 3 shared M. J. Stoltzfus· 3 shared N. C. Keith· 2 shared B. N. A. Opene· 1 shared B. T. K. Nguyen· 1 shared C. W. Euler· 1 shared E. Smith· 1 shared F. P. Breitwieser· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersMicrobiology

J. W. Modell

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4 papers

Recent·Most cited

A dynamic subpopulation of CRISPR-Cas overexpressers allows Streptococcus pyogenes to rapidly respond to phage

M. J. Stoltzfus, R. E. Workman, N. C. Keith, J. W. Modell

The paper identifies a dynamic subpopulation of CRISPR-Cas overexpressers in Streptococcus pyogenes that enhance phage defense but reduce fitness in the absence of phage.

bioRxiv · Jan 11, 2024 · PreprintMicrobiology

Anti-CRISPR proteins trigger a burst of CRISPR-Cas9 expression that enhances phage defense

R. E. Workman, M. J. Stoltzfus, N. C. Keith, C. W. Euler, J. Bondy-Denomy, J. W. Modell

The paper shows anti-CRISPR proteins in S. pyogenes reduce Cas9 autorepression, leading to increased CRISPR-Cas expression and enhanced phage defense.

bioRxiv · Oct 22, 2023Microbiology

Metagenomic Next-Generation Sequencing of Rectal Swabs for the Surveillance of Antimicrobial Resistant Organisms on the Illumina Miseq and Oxford MinION Platforms

R. Yee, F. P. Breitwieser, S. Hao, B. N. A. Opene, R. E. Workman, P. D. Tamma, J. Dien Bard, W. Timp, P. J. Simner

This study evaluates mNGS on Illumina MiSeq and Nanopore MinION platforms for detecting MDRO in rectal swabs, showing concordance with culture results and highlighting advantages of both short and long-read approaches.

European Journal of Clinical Microbiology & Infectious Diseases · Aug 11, 2020Peer-reviewedMicrobiology

A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression

R. E. Workman, T. Pammi, B. T. K. Nguyen, L. W. Graeff, E. Smith, S. M. Sebald, M. J. Stoltzfus, J. W. Modell

The paper shows that a long-form tracrRNA acts as a natural single guide to repress Cas9 expression, revealing a regulatory mechanism in CRISPR-Cas systems.

bioRxiv · May 21, 2020Microbiology