Author

J. W. Modell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

M. J. Stoltzfus· 3 shared R. E. Workman· 3 shared N. C. Keith· 2 shared B. T. K. Nguyen· 1 shared C. W. Euler· 1 shared E. Smith· 1 shared J. Bondy-Denomy· 1 shared L. W. Graeff· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersMicrobiology

M. J. Stoltzfus

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3 papers

Recent·Most cited

A dynamic subpopulation of CRISPR-Cas overexpressers allows Streptococcus pyogenes to rapidly respond to phage

M. J. Stoltzfus, R. E. Workman, N. C. Keith, J. W. Modell

The paper identifies a dynamic subpopulation of CRISPR-Cas overexpressers in Streptococcus pyogenes that enhance phage defense but reduce fitness in the absence of phage.

bioRxiv · Jan 11, 2024 · PreprintMicrobiology

Anti-CRISPR proteins trigger a burst of CRISPR-Cas9 expression that enhances phage defense

R. E. Workman, M. J. Stoltzfus, N. C. Keith, C. W. Euler, J. Bondy-Denomy, J. W. Modell

The paper shows anti-CRISPR proteins in S. pyogenes reduce Cas9 autorepression, leading to increased CRISPR-Cas expression and enhanced phage defense.

bioRxiv · Oct 22, 2023Microbiology

A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression

R. E. Workman, T. Pammi, B. T. K. Nguyen, L. W. Graeff, E. Smith, S. M. Sebald, M. J. Stoltzfus, J. W. Modell

The paper shows that a long-form tracrRNA acts as a natural single guide to repress Cas9 expression, revealing a regulatory mechanism in CRISPR-Cas systems.

bioRxiv · May 21, 2020Microbiology