Author

L. Willmore

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Animal Behavior & Cognition· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Assay:imaging· 1

Frequent Co-Authors

C. Y. Yeh· 2 shared D. E. Shaw· 2 shared J. B. Greisman· 2 shared P. Maragakis· 2 shared D. E. Aldarondo· 1 shared F. Giordanetto· 1 shared H. Nisonoff· 1 shared J. A. Izaguirre· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersBiophysics

C. Y. Yeh

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Author profile →

3 papers

Recent·Most cited

A conserved local structural motif controls the kinetics of PTP1B catalysis

C. Y. Yeh, J. A. Izaguirre, J. B. Greisman, L. Willmore, P. Maragakis, D. E. Shaw

This study identifies the PDFG motif as a conserved structural switch controlling WPD-loop conformational transitions in PTP1B, essential for catalytic activity.

bioRxiv · Feb 28, 2023 · PreprintBiophysics

Discovery and validation of the binding poses of allosteric fragment hits to PTP1b: From molecular dynamics simulations to X-ray crystallography

J. B. Greisman, L. Willmore, C. Y. Yeh, F. Giordanetto, S. Shahamadtar, H. Nisonoff, P. Maragakis, D. E. Shaw

The paper uses molecular dynamics simulations to predict fragment binding poses to PTP1b, which are later validated by X-ray crystallography.

bioRxiv · Nov 14, 2022 · PreprintBiophysics

Fast animal pose estimation using deep neural networks

T. D. Pereira, D. E. Aldarondo, L. Willmore, M. Kislin, S. S.- H. Wang, M. Murthy, J. W. Shaevitz

The paper introduces LEAP, a deep learning method for fast animal pose estimation, validated on fruit flies and mice with high accuracy and speed.

bioRxiv · May 30, 2018Animal Behavior & Cognition