Author

C. Y. Yeh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Approach:biophysical modeling· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

D. E. Shaw· 2 shared J. B. Greisman· 2 shared L. Willmore· 2 shared P. Maragakis· 2 shared A. Wang· 1 shared B. E. Howitt· 1 shared B. Liang· 1 shared F. Giordanetto· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersBiophysics

D. E. Shaw

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Mapping ovarian cancer spatial organization uncovers immune evasion drivers at the genetic, cellular, and tissue level

C. Y. Yeh, K. Aguirre, O. Laveroni, S. Kim, A. Wang, B. Liang, X. Zhang, L. M. Han, R. Valbuena, S. K. Plevritis, M. C. Bassik, M. P. Snyder, B. E. Howitt, L. Jerby

This study maps ovarian cancer spatial organization and identifies immune evasion drivers through single-cell spatial transcriptomics and CRISPR screens.

bioRxiv · Oct 16, 2023Cancer Biology

A conserved local structural motif controls the kinetics of PTP1B catalysis

C. Y. Yeh, J. A. Izaguirre, J. B. Greisman, L. Willmore, P. Maragakis, D. E. Shaw

This study identifies the PDFG motif as a conserved structural switch controlling WPD-loop conformational transitions in PTP1B, essential for catalytic activity.

bioRxiv · Feb 28, 2023 · PreprintBiophysics

Discovery and validation of the binding poses of allosteric fragment hits to PTP1b: From molecular dynamics simulations to X-ray crystallography

J. B. Greisman, L. Willmore, C. Y. Yeh, F. Giordanetto, S. Shahamadtar, H. Nisonoff, P. Maragakis, D. E. Shaw

The paper uses molecular dynamics simulations to predict fragment binding poses to PTP1b, which are later validated by X-ray crystallography.

bioRxiv · Nov 14, 2022 · PreprintBiophysics