Author

J. A. Izaguirre

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

H. Xu· 2 shared A. Dickson· 1 shared A. Evdokimov· 1 shared A. M. Razavi· 1 shared A. Vinitsky· 1 shared B. Mostofian· 1 shared B. Ruprecht· 1 shared C. Y. Yeh· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

H. Xu

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Author profile →

3 papers

Recent·Most cited

BiophysicsbioRxivPreprintFeb 28, 2023

A conserved local structural motif controls the kinetics of PTP1B catalysis

C. Y. Yeh, J. A. Izaguirre, J. B. Greisman…·D. E. Shaw

This study identifies the PDFG motif as a conserved structural switch controlling WPD-loop conformational transitions in PTP1B, essential for catalytic activity.

DOI 10.1101/2023.02.28.529746

biophysical modelingchromatin & epigenetic regulation

𝕏 PostBluesky

BiochemistrybioRxivMar 22, 2022

Modeling the effect of cooperativity in ternary complex formation and targeted protein degradation mediated by heterobifunctional degraders

D. Park, J. A. Izaguirre, R. Coffey, H. Xu

This paper develops a pharmacodynamic model to study how cooperativity affects ternary complex formation and protein degradation mediated by heterobifunctional degraders.

DOI 10.1021/acsbiomedchemau.2c00037

statistical modeldrug response / drug discovery

𝕏 PostBluesky

BiophysicsbioRxivPreprintSep 26, 2021

Atomic-Resolution Prediction of Degrader-mediated Ternary Complex Structures by Combining Molecular Simulations with Hydrogen Deuterium Exchange

T. Dixon, D. MacPherson, B. Mostofian…·J. A. Izaguirre

This paper predicts atomic-resolution structures of degrader-mediated ternary complexes using combined HDX-MS and molecular dynamics simulations, validated by experimental data.

DOI 10.1101/2021.09.26.461830

proteomicsstructural biology

𝕏 PostBluesky