Discovery of a molecular glue that enhances UPRmt to restore proteostasis via TRKA-GRB2-EVI1-CRLS1 axis
L.-F.-R. Qi, C. Qian, S. Liu, C. Peng, M. Zhang, P. Yang, P. Wu, P. Li, X. Xu
This study identifies ginsenoside Rg3 as a molecular glue that enhances mitochondrial UPR via the TRKA-GRB2-EVI1-CRLS1 axis to restore proteostasis in Parkinson's disease.
bioRxiv · Feb 17, 2021 · PreprintPharmacology & Toxicology