Inhibition of early-acting autophagy genes in C. elegans neurons improves protein homeostasis, promotes exopher production, and extends lifespan via the ATG-16.2 WD40 domain
Y. Yang, M. L. Arnold, E. H. Choy, C. M. Lange, K. Poon, M. Broussalian, L.-H. Sun, T. M. Moreno, A. Singh, M. Driscoll, C. Kumsta, M. Hansen
The paper inhibits early-acting autophagy genes in C. elegans neurons, finding that it reduces protein aggregates, increases exopher production, and extends lifespan, with ATG-16.2's WD40 domain being critical for these effects.
bioRxiv · Dec 12, 2022 · PreprintCell Biology