The compact CasPi (Cas12l) bracelet "provides" a unique structural platform for DNA manipulation
A. Sun, C. Li, Z. Chen, S. Zhang, D. Li, Y. Yang, L.-Q. Li, Y. Zhao, K. Wang, Z. Li, J. Liu, S. Liu, J. Wang, J.-J. G. Liu
The paper identifies a new CRISPR-Cas12l system from metagenomes, showing it cleaves DNA with a unique PAM and forms a bracelet structure for gene editing.
bioRxiv · Dec 16, 2022Biophysics