BiophysicsbioRxivPreprint
Experimental umbrella sampling of a rotary nanomachine
Lennart J. K. Weiß, Laetitia Daubner, Niccolò Tedeschi…·Friedrich Christian Simmel
This paper introduces an experimental method to reconstruct free-energy landscapes of rotary DNA nanomachines using electric-field biasing and statistical reweighting, revealing energy barriers and design modifications' effects.
DOI 10.64898/2026.10.15.758702