The CECR2 bromodomain displays distinct binding modes to select for acetylated histone proteins versus non-histone ligands.
Margaret Phillips, Hassan Zafar, Matthew R. Marunde, Elizabeth D. Cook, Marco Tonelli, Laiba Khan, Amy Henrickson, James M. Lignos, Janet Lee Stein, Gary S. Stein, Seth E. Frietze, Borries Demeler, Karen C. Glass
This paper investigates the binding specificity of CECR2-BRD to acetylated histone and non-histone ligands, revealing distinct binding modes and functional roles in chromatin regulation and inflammation.
bioRxiv · Dec 9, 2024 · PreprintBiochemistry