Seth E. Frietze

The paper profiles genome organization changes during breast cancer progression using Micro-C mapping and links these changes to gene expression and enhancer activity.

The paper investigates PABPC1's role in alternative polyadenylation during B cell development, finding it primarily shortens and downregulates its targets in a context-dependent manner.

This study identifies XPO5 as a regulator of B cell receptor surface expression through a genome-wide CRISPRi screen, showing its role in balancing mutagenesis and DNA repair during somatic hypermutation.

The paper identifies MANCR isoforms' roles in epigenomic and P53-responsive transcriptional control in TNBC through computational and experimental methods.

This study shows that acute RUNX1 loss reprograms enhancer activity, leading to epithelial destabilization and cancer hallmark activation in human mammary epithelial cells.

This study investigates how HSV-1 infection remodels microglial transcriptional and epigenetic states, revealing IFN-responsive dominance and loss of homeostatic signatures in specific brain regions.

This study identifies ERG as a vulnerability in IKZF1-mutated B-cell acute lymphoblastic leukemia through gene regulatory network analysis and functional validation.

The paper investigates how HSV-1 CTCF insulators regulate chromatin organization and transcription through long-range cis interactions, showing that deletion of the CTRL2 insulator disrupts chromatin domains and alters transcriptional accessibility.

The paper uses single-cell RNA sequencing and flow cytometry to analyze ovarian immune cells in mice under high and low estradiol states, finding dynamic changes in NK and B cell populations during the periovulatory phase.

This study shows that Schistosoma mansoni antigens induce innate immune training in males but not females, which can be inhibited by ovarian hormones and involves mitochondrial biogenesis.

The paper uses single-nucleus multiome sequencing to study how thermal acclimation affects chromatin accessibility and gene expression in Drosophila embryos, revealing homeostatic mechanisms that enhance heat tolerance.

This paper investigates the binding specificity of CECR2-BRD to acetylated histone and non-histone ligands, revealing distinct binding modes and functional roles in chromatin regulation and inflammation.

This study constructs protein-protein interaction networks for human bromodomain-containing proteins to analyze their functional roles and network properties.

The paper identifies viral infection and inflammation signatures in the olfactory system of familial Alzheimer's disease patients, suggesting their role in disease progression.

The paper identifies three distinct modes of TRβ interaction with chromatin and shows differential recruitment of SWI/SNF complexes in response to thyroid hormone.