Marco Tonelli

Intrinsic conformational equilibria position arrestin-2 for activation

This study identifies two distinct conformational equilibria in arrestin-2 that underlie its pre-activation state in solution.

Host-microbiome mutualism drives urea carbon salvage and acetogenesis during hibernation

This study identifies urea carbon salvage as a mechanism enabling hibernating squirrels to reuse urea and mucins for energy during fasting.

The structure, folding kinetics and dynamics of long poly(UG) RNA

This study investigates the structure, folding kinetics, and dynamics of long poly(UG) RNAs, revealing a dynamic model for segmental register exchange and double pUG fold formation.

Backbone and Sidechain 1H, 15N and 13C Resonance Assignments of a Multidrug Efflux Membrane Protein using Solution and Solid-State NMR

The paper reports NMR resonance assignments for EmrE, a multidrug transporter, using solution and solid-state NMR techniques at specific pH conditions.

In situ light-driven pH modulation for NMR studies

This paper introduces a method to control pH in NMR samples using light-activated photoacids, enabling non-invasive and precise pH modulation for studying protonation states in proteins.

The CECR2 bromodomain displays distinct binding modes to select for acetylated histone proteins versus non-histone ligands.

This paper investigates the binding specificity of CECR2-BRD to acetylated histone and non-histone ligands, revealing distinct binding modes and functional roles in chromatin regulation and inflammation.

An Atypical RNA Quadruplex Marks RNAs as Vectors for Gene Silencing

The paper identifies a novel RNA quadruplex structure, the pUG fold, that drives gene silencing in C. elegans and is present in human non-coding RNAs.