Author

James M. Lignos

University of Vermont

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Karen C. GlassiD· 2 shared Amy HenricksoniD· 1 shared Borries DemeleriD· 1 shared Elizabeth D. Cook· 1 shared Eugene Y. D. ChuaiD· 1 shared Gary S. SteiniD· 1 shared Hassan ZafariD· 1 shared Janet Lee SteiniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Karen C. GlassORCID

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2 papers

Recent·Most cited

Cryo-EM Structure of Human ATAD2B Reveals a Hexameric Organization Contributes to ATPase Activity and Substrate Coordination

Kiera L. Malone, Eugene Y. D. Chua, James M. Lignos, Patricia M. Fagnant, Jill E. Macfarlane, Kathleen M. Trybus, Michael A. Cianfrocco, Karen C. Glass

This study presents the cryo-EM structure of human ATAD2B, revealing its hexameric organization and providing insights into its ATPase activity and substrate coordination.

bioRxiv · Apr 3, 2026 · PreprintBiochemistry

The CECR2 bromodomain displays distinct binding modes to select for acetylated histone proteins versus non-histone ligands.

Margaret Phillips, Hassan Zafar, Matthew R. Marunde, Elizabeth D. Cook, Marco Tonelli, Laiba Khan, Amy Henrickson, James M. Lignos, Janet Lee Stein, Gary S. Stein, Seth E. Frietze, Borries Demeler, Karen C. Glass

This paper investigates the binding specificity of CECR2-BRD to acetylated histone and non-histone ligands, revealing distinct binding modes and functional roles in chromatin regulation and inflammation.

bioRxiv · Dec 9, 2024 · PreprintBiochemistry