PEPITEM Tripeptides and Peptidomimetics: Next-Generation Modulators of Inflammation in Immune-Mediated Conditions
Anella Saviano, Bonita H. R. Apta, Samantha P. Tull, Laleh Pezhman, Areeba Fatima, Mustafa Sevım, Antonio Mete, Myriam Chimen, Anna Schettino, Noemi Marigliano, Helen Michelle McGettrick, Asif Jilani Iqbal, Francesco Μaione, George Ed Rainger
The paper identifies two tripeptide pharmacophores in PEPITEM and shows their engineered peptidomimetics reduce inflammation and immune cell infiltration in models of immune-mediated diseases.
Pharmacological Research · Jan 22, 2025Peer-reviewedImmunology