Helen Michelle McGettrick

Galectin-9 drives thrombo-inflammatory circuits initiating venous thrombosis

This study identifies Galectin-9 as a driver of venous thrombo-inflammation, linking inflammation to thrombus formation through platelet activation and NETosis.

Translational toolkit for reproducible, cross-study profiling of human ageing hallmarks in human blood and tissue

The paper develops a toolkit to measure multiple ageing hallmarks in human blood and tissue samples, identifying age-related changes in immune cells, senescence, and mitochondrial function.

Neutrophil and NET-driven pulmonary microvascular injury following myocardial injury: attenuation by S100A8/A9 inhibition

This study shows that myocardial injury leads to pulmonary microvascular damage driven by neutrophils and S100A8/A9, which can be reduced by inhibiting S100A8/A9.

PEPITEM Tripeptides and Peptidomimetics: Next-Generation Modulators of Inflammation in Immune-Mediated Conditions

The paper identifies two tripeptide pharmacophores in PEPITEM and shows their engineered peptidomimetics reduce inflammation and immune cell infiltration in models of immune-mediated diseases.

Spatial programming of fibroblasts promotes resolution of tissue inflammation through immune cell exclusion

The paper uses multi-omic spatial analysis to identify fibroblast subsets in inflamed synovium that create tissue niches influencing immune cell trafficking and inflammation resolution.