Cell BiologybioRxivPreprint
Coordinate regulation of Activin and Bone Morphogenetic Protein signaling by a lysosomal trafficking switch
Warren W. Hom, Senem Aykul, Lampros Panagis…·Aris N. Economides
The paper shows that ActA forms non-signaling complexes with ACVR1 that are trafficked to lysosomes and degraded, unlike Activin B, AC, and AB which remain on the surface.
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