Reversible disulfide bond crosslinks as tunable levers of phase separation in designer biomolecular condensates.
Malay Mondal, Penelope E. Jankoski, Landon D. Lee, Daniel M. Dinakarapandian, Tzu-Ying Chiu, Windfield S. Swetman, Hongwei Wu, Anant K. Paravastu, Tristan D. Clemons, Vijayaraghavan Rangachari
This study investigates the role of cysteine residues in biomolecular condensates, showing they function as covalent nodes that tune phase separation through redox-sensitive disulfide bonds.
Journal of the American Chemical Society · Aug 28, 2024Peer-reviewedBiophysics