Rare variant in intracellular loop-2 of the ghrelin receptor reveals novel mechanisms of GPCR biased signaling and trafficking
Elsa M Balfe, Alexandre G. Torbey, Lara Kohlenbach, Jade A. Sency, Asuka Inoue, Larry S. Barak, Joshua Gross
The paper characterizes a rare GHSR variant, L149P, revealing novel roles of intracellular loop-2 in GPCR biased signaling, lipid modulation, and trafficking through experimental and computational methods.
bioRxiv · Mar 11, 2025 · PreprintBiochemistry