Author

Joshua Gross

Pennsylvania State UniversityORCID 0000-0002-0925-6331Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1

Frequent Co-Authors

Larry S. BarakiD· 3 shared Lauren M. SloskyiD· 2 shared William C. WetseliD· 2 shared Yang ZhouiD· 2 shared Alexandre G. TorbeyiD· 1 shared Alp Kuzey Sozat· 1 shared Andrea Pires· 1 shared Asuka InoueiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

Larry S. BarakORCID

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3 papers

Recent·Most cited

Hidden Bias: GPCR Polymorphisms and the Genomic Landscape of β- Arrestin Signaling

Yang Zhou, Alp Kuzey Sozat, William C. Wetsel, Lauren M. Slosky, Joshua Gross, Larry S. Barak

The paper identifies SNPs in GPCRs that alter β-arrestin signaling bias and shows their potential impact on phenotypic variation.

bioRxiv · Jun 3, 2025 · PreprintBiochemistry

Rare variant in intracellular loop-2 of the ghrelin receptor reveals novel mechanisms of GPCR biased signaling and trafficking

Elsa M Balfe, Alexandre G. Torbey, Lara Kohlenbach, Jade A. Sency, Asuka Inoue, Larry S. Barak, Joshua Gross

The paper characterizes a rare GHSR variant, L149P, revealing novel roles of intracellular loop-2 in GPCR biased signaling, lipid modulation, and trafficking through experimental and computational methods.

bioRxiv · Mar 11, 2025 · PreprintBiochemistry

Establishment of Multi-stage Intravenous Self-administration in Mice

Lauren M. Slosky, Andrea Pires, Yushi Bai, Nicholas B. Clark, Elizabeth R. Hauser, Joshua Gross, Fiona Porkka, Yang Zhou, Xiaoxiao Chen, Vladimir M. Pogorelov, Krisztián Tóth, William C. Wetsel, Larry S. Barak, Marc G. Caron

This paper establishes a multi-stage IVSA paradigm in mice for studying addiction, showing that behavioral traits predict vulnerability to drug seeking and relapse.

Scientific Reports · Dec 11, 2022Peer-reviewedNeuroscience