Larry S. Barak

This study designs allosteric modulators that alter GPCR G protein subtype selectivity by targeting the receptor-transducer interface, demonstrating predictable mechanisms for rational drug design.

The paper identifies SNPs in GPCRs that alter β-arrestin signaling bias and shows their potential impact on phenotypic variation.

The paper characterizes a rare GHSR variant, L149P, revealing novel roles of intracellular loop-2 in GPCR biased signaling, lipid modulation, and trafficking through experimental and computational methods.

This study shows that cancer progression is nonlinear, with a critical occult transition leading to lethal tumors before detection, challenging the linear model of cancer growth.

This study evaluates the effects of SBI-553, a β-arrestin-biased allosteric modulator of NTSR1, on ethanol-related behaviors in rodents, finding reduced ethanol consumption and altered sensitivity to ethanol effects.

This paper establishes a multi-stage IVSA paradigm in mice for studying addiction, showing that behavioral traits predict vulnerability to drug seeking and relapse.