Loop extrusion by cohesin plays a key role in enhancer-activated gene expression during differentiation
Rosa J. Stolper, Felice Ho‐Ching Tsang, Emily Georgiades, Lars L.P. Hansen, Damien J. Downes, Caroline L. Harrold, Jim R. Hughes, Robert A. Beagrie, Benjamin Davies, Mira T. Kassouf, Douglas R. Higgs
The paper investigates the role of cohesin-mediated loop extrusion in enhancer-promoter proximity and gene expression during mouse erythropoiesis, finding that it is important but not exclusive for gene activation.
bioRxiv · Sep 7, 2023 · PreprintMolecular Biology