Caroline L. Harrold

The paper shows that active enhancers recruit cohesin to form cell-specific chromatin domains, using the alpha globin cluster as a model.

The paper investigates the role of cohesin-mediated loop extrusion in enhancer-promoter proximity and gene expression during mouse erythropoiesis, finding that it is important but not exclusive for gene activation.

The paper shows that super-enhancers function directionally and orientation-dependently, unlike regular enhancers, by analyzing the β-globin super-enhancer.

This paper establishes a scalable protocol to isolate primitive-like erythroid cells from in vitro differentiated mESCs, showing they recapitulate normal erythropoiesis and mutation effects seen in primary cells.

The paper shows that actively transcribed genes can function as chromatin boundary elements, similar to CTCF-bound sites, by stalling chromatin loop extrusion.

The paper investigates promoter competition in the -globin domain using chromatin interaction data, finding that promoters interact simultaneously with a super-enhancer rather than competing.

The paper identifies 14 new bacteriocin gene clusters in Streptococcus pneumoniae genomes and shows their diversity and activity under stress and competition.