Rosa J. Stolper

The characteristics of CTCF binding sequences contribute to enhancer blocking activity

This study identifies CTCF binding sequences that effectively block enhancer-promoter activity, showing that their function is not correlated with CTCF/cohesin levels, conservation, or sequence similarity to consensus motifs.

Loop extrusion by cohesin plays a key role in enhancer-activated gene expression during differentiation

The paper investigates the role of cohesin-mediated loop extrusion in enhancer-promoter proximity and gene expression during mouse erythropoiesis, finding that it is important but not exclusive for gene activation.

Super-enhancers require a combination of classical enhancers and novel facilitator elements to drive high levels of gene expression

The paper investigates the functional interdependence of super-enhancer elements in erythroid -globin gene regulation, revealing the necessity of facilitator elements for optimal activity.

A functional overlap between actively transcribed genes and chromatin boundary elements

The paper shows that actively transcribed genes can function as chromatin boundary elements, similar to CTCF-bound sites, by stalling chromatin loop extrusion.