GSK3β-SCF-FBXW7 mediated phosphorylation and ubiquitination of IRF1 are required for its transcription-dependent turnover.
Alexander J. Garvin, Ahmed Khalaf, Alessandro Rettino, Jérôme Xicluna, Laura Butler, Joanna R. Morris, David M. Heery, Nicole M Clarke
This paper identifies GSK3β-mediated phosphorylation of IRF1 at T181, which promotes its ubiquitination and degradation, essential for its transcriptional activity and anti-proliferative function.
Nucleic Acids Research · Mar 7, 2019Peer-reviewedMolecular Biology