Molecular BiologyNucleic Acids ResearchPeer-reviewed
GSK3β-SCF-FBXW7 mediated phosphorylation and ubiquitination of IRF1 are required for its transcription-dependent turnover.
Alexander J. Garvin, Ahmed Khalaf, Alessandro Rettino…·Nicole M Clarke
This paper identifies GSK3β-mediated phosphorylation of IRF1 at T181, which promotes its ubiquitination and degradation, essential for its transcriptional activity and anti-proliferative function.
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