Author

David M. Heery

University of NottinghamORCID 0000-0002-5035-2392Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Adam Varady· 1 shared Ahmed KhalafiD· 1 shared Alejandro Medaglia Mata· 1 shared Aleksandra Fesiuk· 1 shared Alessandro RettinoiD· 1 shared Alexander J. GarviniD· 1 shared Boglárka SzabóiD· 1 shared Boris TichýiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Adam Varady

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Thyroid Hormone Receptor Beta Signaling is a Targetable Driver of Prostate Cancer Growth

Aleksandra Fesiuk, Daniel Pölöske, Elvin D. de Araujo, Geordon A. Frere, Timothy B. Wright, Gary Tin, Yasir S. Raouf, Olasunkanmi O. Olaoye, Ji Sung Park, Nicolas Blavet, Boris Tichý, Michaela Schlederer, Sandra Högler, Michael Wolf, Cécile Philippe, , Lukas Kenner

This study identifies TRβ as a driver of prostate cancer growth and shows that NH-3 inhibits PCa cell proliferation and tumor growth, particularly in castration-resistant models.

Molecular Cancer · Oct 14, 2025Peer-reviewedCancer Biology

GSK3β-SCF-FBXW7 mediated phosphorylation and ubiquitination of IRF1 are required for its transcription-dependent turnover.

Alexander J. Garvin, Ahmed Khalaf, Alessandro Rettino, Jérôme Xicluna, Laura Butler, Joanna R. Morris, David M. Heery, Nicole M Clarke

This paper identifies GSK3β-mediated phosphorylation of IRF1 at T181, which promotes its ubiquitination and degradation, essential for its transcriptional activity and anti-proliferative function.

Nucleic Acids Research · Mar 7, 2019Peer-reviewedMolecular Biology