Molecular prosthetics for CFTR designed for anion selectivity outperform amphotericin B in cultured cystic fibrosis airway epithelia
Jonnathan P. Marin-Toledo, Daniel M. Greenan, Nohemy Celis, Laura Haske, Agnieszka Lewandowska, Christopher K. Rakowski, Shashank Shastry, Arun Maji, Kelsie J. Green, Taras V. Pogorelov, Michael J. Welsh, Ian M. Thornell, Martin D. Burke
The paper shows that modified amphotericin B derivatives improve ASL pH in CF airway epithelia better than amphotericin B itself.
bioRxiv · Aug 28, 2025 · PreprintPharmacology & Toxicology