Michael J. Welsh

This paper shows that in utero ivacaftor treatment rescues multiple organ defects in CFTR-G551D pigs, improving pancreatic, gallbladder, and vas deferens function.

This study shows that combining CFTR modulators with amphotericin B increases HCO3- secretion and airway surface liquid pH in CF airway epithelia more than either treatment alone.

The paper shows that modified amphotericin B derivatives improve ASL pH in CF airway epithelia better than amphotericin B itself.

This paper develops a PCD pig model with DNAI1 mutations and characterizes its respiratory and sinus disease features, showing similarities to human PCD.

The paper compares gene expression and function of airway cell types in small and large porcine airways, finding distinct transcriptomes and functional roles.