Location of NMDARs and co-agonist controls the generation of bursts in nigral dopamine neurons
Sofian Ringlet, Zoraide Motta, Laura M. Vandries, Vincent Seutin, Kévin Jehasse, Laura Caldinelli, Loredano Pollegioni, Dominique Engel
The paper shows that extrasynaptic NMDARs, activated by glycine and glutamate spillover, drive bursting in nigral dopamine neurons, while synaptic NMDARs use D-serine.
bioRxiv · Jun 6, 2024 · PreprintNeuroscience