Loredano Pollegioni

This study shows that embryonic depletion of D-aspartate in mice leads to increased NMDA receptor-dependent long-term potentiation in juvenile hippocampus, which is reversible with exogenous D-aspartate.

The paper investigates NMDA receptor co-agonism in adolescent prefrontal cortex fast-spiking GABAergic interneurons, revealing distinct co-agonist regulation at different synaptic locations.

BIOINF-farma integrates epitope prediction and developability assessment to prioritize vaccine candidates by combining antigenicity and expression feasibility scores.

The paper shows that extrasynaptic NMDARs, activated by glycine and glutamate spillover, drive bursting in nigral dopamine neurons, while synaptic NMDARs use D-serine.