Dominique Engel

Ccp1 depletion disrupts network integration of hippocampal parvalbumin interneurons

This study shows that Ccp1 depletion in hippocampal parvalbumin interneurons leads to hyperglutamylation, impaired axonal transport, and reduced perisomatic inhibition of pyramidal cells in the CA2 region.

Location of NMDARs and co-agonist controls the generation of bursts in nigral dopamine neurons

The paper shows that extrasynaptic NMDARs, activated by glycine and glutamate spillover, drive bursting in nigral dopamine neurons, while synaptic NMDARs use D-serine.

An unconventional conductance is required for pacemaking of nigral dopamine neurons

The paper identifies an unconventional conductance essential for pacemaking in nigral dopamine neurons using pharmacological evidence and electrophysiological analysis.