Electrophysiological dependent antiarrhythmic drug response in population-based models of paroxysmal atrial fibrillation
Violeta Puche-García, Laura Martinez-Mateu, David Filgueiras Rama, Lucía Romero, Javier Saiz
This study shows that antiarrhythmic drug efficacy in atrial fibrillation depends on patient-specific electrophysiological substrates and rotor dynamics, with drug-induced frequency reduction being a key mechanism.
bioRxiv · Sep 21, 2026 · PreprintBioengineering