Cancer-derived Extracellular Vesicles for Targeted Delivery of EGFRvIII siRNA to Glioblastoma, Comparison of siRNA Loading Methods and Efficiency
Fereshteh Shojaei-Ghahrizjani, Nadim Tawil, Brian Meehan, Laura Montermini, Mohammadrasool Khajeh, A. M. Villa, Janusz W. Rak, Paolo Ciana
This study evaluates methods for loading EGFRvIII siRNA into glioblastoma-derived extracellular vesicles, finding transfection to be the most efficient, but noting no significant tumour shrinkage in vivo.
bioRxiv · Mar 13, 2026 · PreprintPharmacology & Toxicology