Author

Janusz W. Rak

Research Institute of the McGill University Health CentreORCID 0000-0002-2912-5566Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Pharmacology & Toxicology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Atina G. CotéiD· 2 shared Dae‐Kyum KimiD· 2 shared A. M. VillaiD· 1 shared Aaron D. Richardson· 1 shared Adriana San‐MigueliD· 1 shared Alexander O. Tejeda· 1 shared Alice DesbuleuxiD· 1 shared Amélie Dricot· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersNeuroscience

Atina G. CotéORCID

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Author profile →

4 papers

Recent·Most cited

Mapping Parkinson's Disease Progression through Deep Plasma Proteomics and Functional Genomics

Ji‐Sun Kim, Chanhee Jeong, Maria Seo-Hyun Kim, Hye‐Yeon Kim, Seungmin Lee, Kyeong Beom Jo, Wen Luo, Irina Shlaifer, Su Hyeon Ha, Saba Sane, Kyung Ah Woo, Emma J. Lee, Youngjin Lee, Sooyeon Chae, Jisu Han, , Han‐Joon Kim

This study identifies plasma protein biomarkers and mechanistic pathways in Parkinson's disease using deep proteomics and functional genomics.

bioRxiv · Jun 25, 2026 · PreprintNeuroscience

Cancer-derived Extracellular Vesicles for Targeted Delivery of EGFRvIII siRNA to Glioblastoma, Comparison of siRNA Loading Methods and Efficiency

Fereshteh Shojaei-Ghahrizjani, Nadim Tawil, Brian Meehan, Laura Montermini, Mohammadrasool Khajeh, A. M. Villa, Janusz W. Rak, Paolo Ciana

This study evaluates methods for loading EGFRvIII siRNA into glioblastoma-derived extracellular vesicles, finding transfection to be the most efficient, but noting no significant tumour shrinkage in vivo.

bioRxiv · Mar 13, 2026 · PreprintPharmacology & Toxicology

An OSMR-CLIC1 cross talk drives key oncogenic pathways in glioblastoma

Amir Hossein Mansourabadi, Dianbo Qu, Francesca Cianci, Jamie D. Snider, Kamaldeep Randhawa, Laura Raco, Max Kotlyar, Mohammad Al Ayach, Guido Rey, Shridhar Sanghvi, Mark Abovsky, Harpreet Singh, Artee H. Luchman, Dylan E Burger, Janusz W. Rak, , Arezu Jahani‐Asl

This study identifies a bidirectional OSMR-CLIC1 crosstalk that drives oncogenic pathways in glioblastoma and suggests targeting this interaction as a therapeutic strategy.

bioRxiv · Mar 5, 2025 · PreprintNeuroscience

A reference map of the human protein interactome

Katja Luck, Dae‐Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana M. Cafarelli, Francisco Jose Campos-Laborie, Benoît Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven J. Deimling, Alice Desbuleux, , Michael A. Calderwood

The paper presents HuRI, a comprehensive human protein-protein interaction map, and demonstrates its utility in understanding cellular function and disease mechanisms.

bioRxiv · Apr 19, 2019 · PreprintSystems Biology