Author

Laura Sala

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:CRISPR screen· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Joana Alves VidigaliD· 3 shared Mahendra Kumar PrajapatiD· 2 shared Alexendar R. PereziD· 1 shared Gaspare La RoccaiD· 1 shared Manish KumariD· 1 shared Michael J. KruhlakiD· 1 shared Parirokh AwasthiiD· 1 shared Rachel L. CosbyiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersGenetics

Joana Alves VidigalORCID

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Author profile →

3 papers

Recent·Most cited

The small non-coding RNA Vaultrc5 is dispensable to mouse development

Mahendra Kumar Prajapat, Laura Sala, Joana Alves Vidigal

This study shows that mice lacking Vaultrc5 are viable and normal but have reduced platelet counts, suggesting a role for vRNAs in hematopoiesis.

RNA · Aug 29, 2024Peer-reviewedGenetics

AGO2 silences mobile transposons in the nucleus of quiescent cells

Laura Sala, Manish Kumar, Mahendra Kumar Prajapat, Srividya Chandrasekhar, Rachel L. Cosby, Gaspare La Rocca, Todd S. Macfarlan, Parirokh Awasthi, Raj Chari, Michael J. Kruhlak, Joana Alves Vidigal

The paper shows AGO2 localizes to the nucleus in quiescent cells to silence mobile transposons via RNA interference.

Nature Structural & Molecular Biology · Nov 20, 2023Peer-reviewedMolecular Biology

Computational correction of off-targeting for CRISPR-Cas9 essentiality screens

Alexendar R. Perez, Laura Sala, Richard K. Perez, Joana Alves Vidigal

The paper develops a computational method to correct off-target effects in CRISPR-Cas9 essentiality screens, improving specificity while preserving known gene essentialities.

bioRxiv · Jul 3, 2020 · PreprintGenomics