Joana Alves Vidigal

The paper shows that inhibiting the HMWR complex causes mitotic defects and enhances cancer cell vulnerability when combined with genotoxic agents.

The paper shows that CRISPR-based methods for studying miRNA binding sites in isogenic cell lines are unreliable due to high variability between replicates.

This study shows that mice lacking Vaultrc5 are viable and normal but have reduced platelet counts, suggesting a role for vRNAs in hematopoiesis.

The paper shows AGO2 localizes to the nucleus in quiescent cells to silence mobile transposons via RNA interference.

This study develops a genetic tool to reversibly inhibit miRNA-mediated gene repression in vivo and shows tissue-specific dependencies on miRNA function for homeostasis and regeneration.

The paper develops a computational method to correct off-target effects in CRISPR-Cas9 essentiality screens, improving specificity while preserving known gene essentialities.