Author

Mahendra Kumar Prajapat

National Institutes of HealthORCID 0000-0002-8090-6552Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Organism:human· 1

Frequent Co-Authors

Joana Alves VidigaliD· 3 shared Laura Sala· 2 shared Andréa Gutierrez MariaiD· 1 shared Gaspare La RoccaiD· 1 shared Manish KumariD· 1 shared Michael J. KruhlakiD· 1 shared Parirokh AwasthiiD· 1 shared Rachel L. CosbyiD· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersGenetics

Joana Alves VidigalORCID

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3 papers

Recent·Most cited

CRISPR-based dissection of miRNA binding sites using isogenic cell lines is hampered by pervasive noise.

Mahendra Kumar Prajapat, Andréa Gutierrez Maria, Joana Alves Vidigal

The paper shows that CRISPR-based methods for studying miRNA binding sites in isogenic cell lines are unreliable due to high variability between replicates.

Nucleic Acids Research · Dec 2, 2024Peer-reviewedGenetics

The small non-coding RNA Vaultrc5 is dispensable to mouse development

Mahendra Kumar Prajapat, Laura Sala, Joana Alves Vidigal

This study shows that mice lacking Vaultrc5 are viable and normal but have reduced platelet counts, suggesting a role for vRNAs in hematopoiesis.

RNA · Aug 29, 2024Peer-reviewedGenetics

AGO2 silences mobile transposons in the nucleus of quiescent cells

Laura Sala, Manish Kumar, Mahendra Kumar Prajapat, Srividya Chandrasekhar, Rachel L. Cosby, Gaspare La Rocca, Todd S. Macfarlan, Parirokh Awasthi, Raj Chari, Michael J. Kruhlak, Joana Alves Vidigal

The paper shows AGO2 localizes to the nucleus in quiescent cells to silence mobile transposons via RNA interference.

Nature Structural & Molecular Biology · Nov 20, 2023Peer-reviewedMolecular Biology