Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold.
Yaw Bia Tan, Laura Sandra Lello, Xin Liu, Yee-Song Law, CongBao Kang, Julien Lescar, Jie Zheng, Andres Merits, Dahai Luo
The paper reports crystal structures of alphavirus nsP4 RNA polymerase domains and identifies dynamic regions critical for RNA replication.
Nucleic Acids Research · Dec 23, 2021Peer-reviewedMolecular Biology