Yaw Bia Tan

This paper presents a cryo-EM structure of the Chikungunya virus replication complex, revealing two distinct RNA-binding sites involved in genome import and replication elongation.

This paper identifies potent benzamide compounds against Zika virus by targeting NS4B, showing superior potency and novel resistance mutation patterns compared to existing treatments.

This study shows that Chikungunya virus nsP1 preferentially binds to positively curved membranes, enabling saddle curvature association critical for replication complex assembly.

The paper reports crystal structures of alphavirus nsP4 RNA polymerase domains and identifies dynamic regions critical for RNA replication.