Secreted Clever-1 Modulates T Cell Responses and Impacts Cancer Immunotherapy Efficacy
Stuart Prince, Miro Viitala, Riikka Sjöroos, Ábris Ádám Bendes, Jenna H. Rannikko, Daniel A. Patten, Ilaria di Benedetto, Rita Turpin, Arno Ylitalo, Laura Tyni, Carlos R. Figueiredo, Pia Boström, Ilkka Koskivuo, Tiina Annamaria Salminen, Shishir Shetty, Maija Hollmén
This study identifies a secreted form of Clever-1 that suppresses T cell responses and reduces anti-PD-1 efficacy in cancer, suggesting it as a therapeutic target and biomarker.
Theranostics · Jun 23, 2025Peer-reviewedImmunology