Author

Daniel A. Patten

University Hospitals Birmingham NHS Foundation TrustORCID 0000-0002-8745-0578Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Shishir ShettyiD· 2 shared Ábris Ádám BendesiD· 1 shared Adriano Giorgio RossiiD· 1 shared Arno YlitaloiD· 1 shared Atsunori TsuchiyaiD· 1 shared Ben Higgins· 1 shared Carlos R. FigueiredoiD· 1 shared David R. WithersiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

Shishir ShettyORCID

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2 papers

Recent·Most cited

Regulatory T cell stability determines the efficiency of bile duct regeneration during cholangitis.

Naruhiro Kimura, Man Chun Wong, Ben Higgins, Gareth R. Hardisty, Pei-Chi Huang, Matamoana Muller, Maxym Besh, Daniel A. Patten, Timothy James Kendall, Prakash Ramachandran, Adriano Giorgio Rossi, Graham Anderson, Shishir Shetty, David R. Withers, Atsunori Tsuchiya, , Wei‐Yu Lu

This study shows that regulatory T cells (Tregs) influence bile duct regeneration during cholangitis, and their stability is critical for reducing fibrosis and inflammation.

Cell Reports · Nov 1, 2025Peer-reviewedImmunology

Secreted Clever-1 Modulates T Cell Responses and Impacts Cancer Immunotherapy Efficacy

Stuart Prince, Miro Viitala, Riikka Sjöroos, Ábris Ádám Bendes, Jenna H. Rannikko, Daniel A. Patten, Ilaria di Benedetto, Rita Turpin, Arno Ylitalo, Laura Tyni, Carlos R. Figueiredo, Pia Boström, Ilkka Koskivuo, Tiina Annamaria Salminen, Shishir Shetty, Maija Hollmén

This study identifies a secreted form of Clever-1 that suppresses T cell responses and reduces anti-PD-1 efficacy in cancer, suggesting it as a therapeutic target and biomarker.

Theranostics · Jun 23, 2025Peer-reviewedImmunology