Maija Hollmén

Clever-1 blockade disrupts lipid metabolism and mitochondrial fitness in acute myeloid leukemia

This study shows Clever-1 inhibition disrupts mitochondrial function and lipid metabolism in AML, making it a potential therapeutic target.

Multimodal immunopharmacologic screens identify drugs rewiring the cancer-immune interface

The paper identifies drugs that rewiring the cancer-immune interface by enhancing NK cell function and tumor susceptibility through multimodal screening approaches.

Positron emission tomography (PET) tracer enables imaging of high CD73 expression in cancer

This paper develops a PET tracer for imaging CD73 expression in cancer, showing improved specificity and diagnostic accuracy compared to [18F]FDG.

YAP/TEAD drives treatment-induced adaptive immunosuppression in EGFR-mutant lung cancer

This study shows that DTP cells in EGFR-mutant lung cancer drive immunosuppression through YAP/TEAD activity, and co-targeting YAP/TEAD improves EGFR TKI therapy efficacy.

Breast Cancer Remodels Lymphatics in Sentinel Lymph Nodes

This study identifies changes in lymphatic endothelial cell subsets and increased MGP expression in metastatic sentinel lymph nodes from breast cancer patients.

Secreted Clever-1 Modulates T Cell Responses and Impacts Cancer Immunotherapy Efficacy

This study identifies a secreted form of Clever-1 that suppresses T cell responses and reduces anti-PD-1 efficacy in cancer, suggesting it as a therapeutic target and biomarker.

Patient-derived tumor explant models of tumor immune microenvironment reveal distinct and reproducible immunotherapy responses

The paper evaluates immunomodulatory drug responses in patient-derived tumor explant models of breast and renal cancer, finding reproducible gene expression and cytokine changes across models.

QClus: A droplet-filtering algorithm for enhanced snRNA-seq data quality in challenging samples

QClus improves snRNA-seq data quality by filtering droplets in challenging samples, achieving high quality across multiple datasets and metrics.

Cardiovascular disease causes proinflammatory microvascular changes in the human right atrium

The paper uses single-nuclei RNA-seq and spatial transcriptomics to analyze gene expression changes in the right atrium of patients with ischemic heart disease, revealing inflammatory microvascular dysfunction and altered tissue composition.

Biallelic STAB1 pathogenic variants cause hereditary hyperferritinemia

The paper identifies biallelic STAB1 mutations as a genetic cause of inherited hyperferritinemia without iron overload.