Cell BiologyCell Death and DifferentiationPeer-reviewed
Partial Bypass of Frataxin Deficiency by ISCU M141I Restores Cytosolic and Nuclear FeS Cluster Assembly
Valentine Mosbach, Nunziata Maio, Lucie Hermet…·Hélène M. Puccio
The paper shows that the ISCU M141I variant partially rescues Fe-S cluster assembly in FXN-deficient cells, preserving nuclear and cytosolic Fe-S proteins but not mitochondrial function.
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