Evolutionary double-bind treatment using radiotherapy and NK cell-based immunotherapy in prostate cancer
Kimberly A Luddy, Jeffrey West, Mark Robertson-Tessi, Bina Desai, Taylor M. Bursell, Sarah Barrett, Jacintha O’Sullivan, Laure Marignol, Robert A Gatenby, Joel S Brown, Alexander RA Anderson, Cliona O’Farrelly
This study combines radiotherapy and NK cell immunotherapy to exploit an evolutionary double-bind strategy in prostate cancer, showing that RT-resistant cells become more vulnerable to NK cell killing.
bioRxiv · Mar 11, 2024 · PreprintCancer Biology